RossD, welcome and thanks for your post!
It is informative and does give some hope. Sorry to here about your condition(s) but I'm glad it doesn't stop you.
(ME/CFS is what I have so for me it's more of a fatigue issue than limited mobility.)
Thanks to the rest of you also.
The Motion Comfort ratio is interesting although I find it difficult to relate it to anything familiar.
What I was going for in my original post was (is) if there is a meaningful way to measure the fatigue caused by discomfort as opposed to fatigue due to handling big sails and a heavy boat but maybe this is not possible, or perhaps the line goes somewhere at 25-30 feet?
In some other post I read that the effort for sailhandling doubles when OAL goes from 30 to 35 feet...
Also the comment about IOR-based boats may relate to a statement by Alberg I read somewhere where he said that he designed his boats to sail well
without six gorillas hanging over the side 
.